Metrics details. Detailed characterization of the cellular composition of the tumor microenvironment is critical to the understanding of the disease and treatment of the patient. Single-cell transcriptomics has been used to study the cellular composition of different solid tumor types including PDAC. However, almost all of those studies used primary tumor tissues.
Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures
Massively parallel nanowell-based single-cell gene expression profiling | BMC Genomics | Full Text
Metrics details. There is increasing evidence that the intestinal microbiota plays a crucial role in the maturation of the immune system and the prevention of diseases during childhood. Early-life short-course antibiotic use may affect the progression of subsequent disease conditions by changing both host microbiota and immunologic development. Epidemiologic studies provide evidence that early-life antibiotic exposures predispose to inflammatory bowel disease IBD. By using a murine model of dextran sodium sulfate DSS -induced colitis, we evaluated the effect on disease outcomes of early-life pulsed antibiotic treatment PAT using tylosin, a macrolide and amoxicillin, a beta-lactam. We evaluated microbiota effects at the 16S rRNA gene level, and intestinal T cells by flow cytometry.
A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis
Ovarian cancer is the 5th leading cause of death of women due to cancer in the United States. Although carbohydrate antigen has a moderate diagnostic utility, the phenomenon of false-positive exists. As novel effective biomarkers, some single microRNAs miRNAs have diagnostic values for ovarian cancer, but the results lack consistency. In order to precisely and comprehensively assess the diagnostic value of single miRNAs for ovarian cancer, a meta-analysis is performed. Articles concerning the diagnostic value of single miRNAs for ovarian cancer were searched from databases.